Mixed protein-DNA gel particles for DNA delivery: role of protein composition and preparation method on biocompatibility.

Morán, M C; Nogueira, D R; Vinardell, M P; Miguel, M G; Lindman, B

Morán, M C; Nogueira, D R; Vinardell, M P; Miguel, M G; Lindman, B.

Affiliation

Morán MC; Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Avda. Joan XXIII, 08028 Barcelona, Spain. mcmoranb@ub.edu

Int J Pharm ; 454(1): 192-203, 2013 Sep 15.

Article in En | MEDLINE | ID: mdl-23811132

Subject(s)

DNA/metabolism; Muramidase/metabolism; Protamines/metabolism; Transfection/methods; Animals; Biological Transport; Cell Survival/drug effects; DNA/chemistry; DNA/toxicity; Dose-Response Relationship, Drug; Erythrocytes/drug effects; Fibroblasts/drug effects; Gels; HeLa Cells; Hemolysis/drug effects; Humans; Mice; Muramidase/chemistry; Muramidase/toxicity; NIH 3T3 Cells; Particle Size; Protamines/chemistry; Protamines/toxicity; Time Factors

Key words

DNA gels; Haemolysis; In vitro cytotoxicity; Particles; Size

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Protamines / Transfection / Muramidase Limits: Animals / Humans Language: En Journal: Int J Pharm Year: 2013 Document type: Article Affiliation country: Spain Country of publication: Netherlands

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