Early phosphoproteomic changes in the mouse spleen during deoxynivalenol-induced ribotoxic stress.

Pan, Xiao; Whitten, Douglas A; Wu, Ming; Chan, Christina; Wilkerson, Curtis G; Pestka, James J

Pan, Xiao; Whitten, Douglas A; Wu, Ming; Chan, Christina; Wilkerson, Curtis G; Pestka, James J.

Affiliation

Pan X; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA.

Toxicol Sci ; 135(1): 129-43, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23811945

Subject(s)

Proteomics; Ribosomes/drug effects; Spleen/drug effects; Stress, Physiological/drug effects; Trichothecenes/toxicity; Animals; Apoptosis/drug effects; MAP Kinase Signaling System; Male; Mice; Phosphatidylinositol 3-Kinases/physiology; Phosphorylation; Proto-Oncogene Proteins c-akt/physiology; Spleen/metabolism

Key words

deoxynivalenol.; phosphorylation; quantitative proteomics; ribotoxic stress response; trichothecene mycotoxin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribosomes / Spleen / Stress, Physiological / Trichothecenes / Proteomics Type of study: Prognostic_studies Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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