Skepinone-L, a novel potent and highly selective inhibitor of p38 MAP kinase, effectively impairs platelet activation and thrombus formation.

Borst, Oliver; Walker, Britta; Münzer, Patrick; Russo, Antonella; Schmid, Evi; Faggio, Caterina; Bigalke, Boris; Laufer, Stefan; Gawaz, Meinrad; Lang, Florian

Borst, Oliver; Walker, Britta; Münzer, Patrick; Russo, Antonella; Schmid, Evi; Faggio, Caterina; Bigalke, Boris; Laufer, Stefan; Gawaz, Meinrad; Lang, Florian.

Affiliation

Borst O; Department of Physiology, University of Tübingen, Gmelinstrasse 5, Tübingen, Germany.

Cell Physiol Biochem ; 31(6): 914-24, 2013.

Article in En | MEDLINE | ID: mdl-23817201

Subject(s)

Blood Platelets/drug effects; Dibenzocycloheptenes/pharmacology; Protein Kinase Inhibitors/pharmacology; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology; Adenosine Triphosphate/metabolism; Blood Platelets/metabolism; Calcium/metabolism; Carrier Proteins/pharmacology; Fura-2/chemistry; HSP27 Heat-Shock Proteins/metabolism; Humans; Peptides/pharmacology; Phospholipases A2/metabolism; Phosphorylation/drug effects; Platelet Activation/drug effects; Platelet Aggregation/drug effects; Shear Strength/drug effects; Thrombin/pharmacology; Thrombosis/metabolism; Thrombosis/pathology; Thromboxane B2/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / P38 Mitogen-Activated Protein Kinases / Protein Kinase Inhibitors / Dibenzocycloheptenes Limits: Humans Language: En Journal: Cell Physiol Biochem Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2013 Document type: Article Affiliation country: Germany Country of publication: Germany

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