Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect.

Karaki, Fumika; Ohgane, Kenji; Dodo, Kosuke; Hashimoto, Yuichi

Karaki, Fumika; Ohgane, Kenji; Dodo, Kosuke; Hashimoto, Yuichi.

Affiliation

Karaki F; Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Bioorg Med Chem ; 21(17): 5297-309, 2013 Sep 01.

Article in En | MEDLINE | ID: mdl-23830695

Subject(s)

Anticholesteremic Agents/chemistry; Membrane Proteins/metabolism; Anticholesteremic Agents/chemical synthesis; Anticholesteremic Agents/pharmacology; Azetidines/pharmacology; Binding Sites; Biological Transport/drug effects; Carbamates/chemical synthesis; Carbamates/chemistry; Carbamates/pharmacology; Ezetimibe; HEK293 Cells; Humans; Ligands; Membrane Proteins/chemistry; Membrane Proteins/genetics; Membrane Transport Proteins; Mutation; Steroids/chemistry; Structure-Activity Relationship

Key words

Cholesterol; Niemann-Pick disease type C; Niemann-Pick type C1-like 1; Protein trafficking; Transporter

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Proteins / Anticholesteremic Agents Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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