Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes, III: Evaluation of the mammary tumor inhibiting properties.
Arch Pharm (Weinheim)
; 323(5): 301-6, 1990 May.
Article
in En
| MEDLINE
| ID: mdl-2383173
ABSTRACT
Diastereomeric diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) sulfates and nitrates produce a strong inhibition of the hormone-dependent MXT-M 3.2 mammary carcinoma of the B6D2F1 mouse. Besides an interference in the DNA synthesis in analogy to cisplatin a lowering of the estrogen level due to an interference in steroid biosynthesis is suggested as the mode of action. In contrast to the R,R/S,S configurated diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) salts the corresponding R,S configurated compounds are also markedly active on the hormone-independent MXT-Ovex mammary carcinoma of the B6D2F1 mouse.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organoplatinum Compounds
/
Ethylenediamines
/
Mammary Neoplasms, Experimental
/
Antineoplastic Agents
Limits:
Animals
Language:
En
Journal:
Arch Pharm (Weinheim)
Year:
1990
Document type:
Article