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Restoration of the activated Rig-I pathway in hepatitis C virus (HCV) replicon cells by HCV protease, polymerase, and NS5A inhibitors in vitro at clinically relevant concentrations.
Kalkeri, Gururaj; Lin, Chao; Gopilan, Jenna; Sloan, Kevin; Rijnbrand, Rene; Kwong, Ann D.
Affiliation
  • Kalkeri G; Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, USA. gururaj_kalkeri@vrtx.com
Antimicrob Agents Chemother ; 57(9): 4417-26, 2013 Sep.
Article in En | MEDLINE | ID: mdl-23836176
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatocytes / Adaptor Proteins, Signal Transducing / Enzyme Inhibitors / Interferon Regulatory Factor-3 / DEAD-box RNA Helicases / Mitochondria Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatocytes / Adaptor Proteins, Signal Transducing / Enzyme Inhibitors / Interferon Regulatory Factor-3 / DEAD-box RNA Helicases / Mitochondria Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States