Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe.

Bhowmik, Shiva; Jones, David H; Chiu, Hsien-Po; Park, In-Hee; Chiu, Hsiu-Ju; Axelrod, Herbert L; Farr, Carol L; Tien, Henry J; Agarwalla, Sanjay; Lesley, Scott A

Bhowmik, Shiva; Jones, David H; Chiu, Hsien-Po; Park, In-Hee; Chiu, Hsiu-Ju; Axelrod, Herbert L; Farr, Carol L; Tien, Henry J; Agarwalla, Sanjay; Lesley, Scott A.

Affiliation

Bhowmik S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, 92037; Joint Center for Structural Genomics.

Proteins ; 82(2): 216-29, 2014 Feb.

Article in En | MEDLINE | ID: mdl-23836456

Subject(s)

Bacterial Proteins/chemistry; Bile Acids and Salts/biosynthesis; Clostridium/enzymology; Hydroxysteroid Dehydrogenases/chemistry; Apoenzymes/chemistry; Catalytic Domain; Crystallography, X-Ray; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; NAD/chemistry

Key words

gut microbe mediated human metabolite; nicotinamide-hydroxyl adduct; primary bile acid; proton relay; secondary bile acid; short-chain dehydrogenase/reductase; steroid dehydrogenase

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Bile Acids and Salts / Clostridium / Hydroxysteroid Dehydrogenases Limits: Humans Language: En Journal: Proteins Journal subject: BIOQUIMICA Year: 2014 Document type: Article Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google