Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2.

Iqbal, Mohd Askandar; Siddiqui, Farid Ahmad; Gupta, Vibhor; Chattopadhyay, Shilpi; Gopinath, Prakasam; Kumar, Bhupender; Manvati, Siddharth; Chaman, Noor; Bamezai, Rameshwar N K

Iqbal, Mohd Askandar; Siddiqui, Farid Ahmad; Gupta, Vibhor; Chattopadhyay, Shilpi; Gopinath, Prakasam; Kumar, Bhupender; Manvati, Siddharth; Chaman, Noor; Bamezai, Rameshwar N K.

Affiliation

Iqbal MA; National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.

Mol Cancer ; 12: 72, 2013 Jul 09.

Article in En | MEDLINE | ID: mdl-23837608

Subject(s)

Insulin/pharmacology; Neoplasms/metabolism; Pyruvate Kinase/metabolism; Cell Line, Tumor; Enzyme Activation/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Glycolysis/drug effects; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Isoenzymes; Models, Biological; NADP/metabolism; Neoplasms/enzymology; Neoplasms/genetics; Phosphatidylinositol 3-Kinases/metabolism; Protein Subunits/chemistry; Protein Subunits/metabolism; Pyruvate Kinase/chemistry; Pyruvate Kinase/genetics; Reactive Oxygen Species/metabolism; TOR Serine-Threonine Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvate Kinase / Insulin / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Cancer Journal subject: NEOPLASIAS Year: 2013 Document type: Article Affiliation country: India Country of publication: United kingdom

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