Interleukin-6 concentration changes in plasma and saliva in bisphosphonate-related osteonecrosis of the jaws.
Oral Dis
; 20(5): 446-52, 2014 Jul.
Article
in En
| MEDLINE
| ID: mdl-23837828
ABSTRACT
AIM:
To determine the plasma and saliva levels of IL-6 in patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) and to investigate whether there is a correlation between more advanced stages of BRONJ and levels of IL-6. MATERIAL ANDMETHODS:
We studied three groups group 1 consisted of 30 patients with BRONJ due to intravenous bisphosphonates (ivBP), group 2 consisted of 25 patients treated with ivBP but without BRONJ, and group 3 consisted of 15 healthy controls. In each case, we assayed plasma and saliva IL-6 samples using an ELISA test.RESULTS:
Significantly, higher IL-6 values were found in both saliva and plasma in group 1 vs groups 2 and 3 (P < 0.01). Group 1 showed no differences in plasma or saliva IL-6 according to patient gender (P > 0.05), type of tumor, BRONJ location, etiology of BRONJ, or disease stage (P > 0.05). We found higher plasma and saliva IL-6 values in the more advances stages of BRONJ, although the differences were not statistically significant.CONCLUSIONS:
Plasma and saliva IL-6 values were higher in our patients with BRONJ than in controls and therefore might be a useful tool for monitoring the severity of BRONJ.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saliva
/
Interleukin-6
/
Bisphosphonate-Associated Osteonecrosis of the Jaw
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Oral Dis
Journal subject:
ODONTOLOGIA
Year:
2014
Document type:
Article
Affiliation country:
Spain