Novel antimicrobial metabolites produced by Sika deer-associated Actinomyces sp. JN411010.
Nat Prod Res
; 27(23): 2183-9, 2013.
Article
in En
| MEDLINE
| ID: mdl-23859601
ABSTRACT
Three novel metabolites (1, 5 and 10) were isolated from a 25-L fermentation broth of Actinomyces sp. JN411010 together with 11 related compounds. Their structures were determined on the basis of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data analyses. Compounds 1-2, 5-8 and 10 displayed moderate antimicrobial activities against Gram-positive and Gram-negative bacteria. Biosynthetic pathway of 5 and 10 was proposed to be catalysed by polyketide and non-ribosomal peptide gene clusters, respectively.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Deer
/
Actinobacteria
/
Anti-Bacterial Agents
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Nat Prod Res
Year:
2013
Document type:
Article