Levels of heroin and its metabolites in blood and brain extracellular fluid after i.v. heroin administration to freely moving rats.

Gottås, A; Øiestad, E L; Boix, F; Vindenes, V; Ripel, Å; Thaulow, C H; Mørland, J

Gottås, A; Øiestad, E L; Boix, F; Vindenes, V; Ripel, Å; Thaulow, C H; Mørland, J.

Affiliation

Gottås A; Department of Drug Abuse Research and Method Development, Division of Forensic Medicine and Drug Abuse Research, Norwegian Institute of Public Health, Oslo, Norway.

Br J Pharmacol ; 170(3): 546-56, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23865556

Subject(s)

Analgesics, Opioid/administration & dosage; Analgesics, Opioid/pharmacology; Brain/metabolism; Extracellular Fluid/metabolism; Heroin/administration & dosage; Heroin/blood; Heroin/pharmacokinetics; Motor Activity; Administration, Intravenous; Analgesics, Opioid/blood; Animals; Biotransformation; Chromatography, Liquid; Male; Morphine Derivatives/blood; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

Key words

CNS; acetylmorphine; distribution; heroin; metabolite kinetic; microdialysis; morphine; opioid; pharmacokinetic; prodrug

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Extracellular Fluid / Heroin / Analgesics, Opioid / Motor Activity Limits: Animals Language: En Journal: Br J Pharmacol Year: 2013 Document type: Article Affiliation country: Norway

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