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Clinical significance of aberrant vimentin expression in oral premalignant lesions and carcinomas.
Sawant, S S; Vaidya, M m; Chaukar, D A; Alam, H; Dmello, C; Gangadaran, P; Kannan, S; Kane, S; Dange, P P; Dey, N; Ranganathan, K; D'Cruz, A K.
Affiliation
  • Sawant SS; Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Kharghar, Navi Mumbai, India.
Oral Dis ; 20(5): 453-65, 2014 Jul.
Article in En | MEDLINE | ID: mdl-23865921
OBJECTIVE: To investigate the clinical significance of vimentin expression at early and late events of tobacco/areca nut-associated oral tumorigenesis. MATERIALS AND METHODS: Immunohistochemistry (IHC) was carried out on paraffin-embedded tissues of oral mucosa normal (n = 10), inflammatory lesions (n = 19), leukoplakia (n = 52), submucous fibrosis (n = 71) and tumours/cut margins (n = 227 each), using anti-vimentin antibody, and the expression profile was correlated with patients' clinical parameters. Immunofluorescence, Western blot and RT-PCR analysis were also carried out wherever adequate and fresh tissues were available. RESULTS: Aberrant vimentin expression was seen in hyperplastic, dysplastic and fibrotic tissues, which showed statistically significant correlation with the histopathological grade of dysplasia (P = 0.001) and fibrosis (P = 0.009). Vimentin expression also showed statistically significant correlation with tumour size (P = 0.048), clinical stage (P = 0.013), regional lymph node metastases (P = 0.001), local recurrence (P = 0.001) and survival (P = 0.021) of patients with oral squamous cell carcinoma (OSCC). Its expression in invasive fronts statistically correlated with development of nodal metastasis and local recurrence. CONCLUSIONS: Our results suggest possible role of vimentin in early events of tobacco/areca nut-associated oral tumorigenesis, which may prove useful to predict the malignant potential of high-risk oral lesions. Further, association between vimentin expression in invasive fronts and aggressive phenotype of tumours may help clinicians to choose the appropriate treatment modality for OSCC management.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precancerous Conditions / Vimentin / Mouth Neoplasms Type of study: Prognostic_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Oral Dis Journal subject: ODONTOLOGIA Year: 2014 Document type: Article Affiliation country: India Country of publication: Denmark

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precancerous Conditions / Vimentin / Mouth Neoplasms Type of study: Prognostic_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Oral Dis Journal subject: ODONTOLOGIA Year: 2014 Document type: Article Affiliation country: India Country of publication: Denmark