Berberine Targets AP-2/hTERT, NF-&#954;B/COX-2, HIF-1&#945;/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth.

Fu, Lingyi; Chen, Wangbing; Guo, Wei; Wang, Jingshu; Tian, Yun; Shi, Dingbo; Zhang, Xiaohong; Qiu, Huijuan; Xiao, Xiangsheng; Kang, Tiebang; Huang, Wenlin; Wang, Shusen; Deng, Wuguo

Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth.

Fu, Lingyi; Chen, Wangbing; Guo, Wei; Wang, Jingshu; Tian, Yun; Shi, Dingbo; Zhang, Xiaohong; Qiu, Huijuan; Xiao, Xiangsheng; Kang, Tiebang; Huang, Wenlin; Wang, Shusen; Deng, Wuguo.

Affiliation

Fu L; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.

PLoS One ; 8(7): e69240, 2013.

Article in En | MEDLINE | ID: mdl-23869238

Subject(s)

Antineoplastic Agents/pharmacology; Berberine/pharmacology; Carcinoma, Non-Small-Cell Lung/pathology; Cell Proliferation/drug effects; Lung Neoplasms/pathology; Signal Transduction/drug effects; Antineoplastic Agents/therapeutic use; Apoptosis/drug effects; Berberine/therapeutic use; Carcinoma, Non-Small-Cell Lung/drug therapy; Carcinoma, Non-Small-Cell Lung/metabolism; Caspases/metabolism; Cell Line, Tumor; Cell Movement/drug effects; Cyclooxygenase 2/metabolism; Cytochromes c/metabolism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Lung Neoplasms/drug therapy; Lung Neoplasms/metabolism; NF-kappa B/metabolism; Telomerase/metabolism; Transcription Factor AP-2/metabolism; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Berberine / Signal Transduction / Carcinoma, Non-Small-Cell Lung / Cell Proliferation / Lung Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: China Country of publication: United States

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