II. Technological approaches to improve the dissolution behavior of nateglinide, a lipophilic insoluble drug: co-milling.

Maggi, Lauretta; Bruni, Giovanna; Maietta, Mariarosa; Canobbio, Andrea; Cardini, Andrea; Conte, Ubaldo

Maggi, Lauretta; Bruni, Giovanna; Maietta, Mariarosa; Canobbio, Andrea; Cardini, Andrea; Conte, Ubaldo.

Affiliation

Maggi L; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.

Int J Pharm ; 454(1): 568-72, 2013 Sep 15.

Article in En | MEDLINE | ID: mdl-23872227

Subject(s)

Cyclohexanes/chemistry; Hypoglycemic Agents/chemistry; Phenylalanine/analogs & derivatives; Technology, Pharmaceutical/methods; Carboxymethylcellulose Sodium/chemistry; Chemistry, Pharmaceutical; Cyclohexanes/administration & dosage; Drug Carriers; Excipients/chemistry; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hypoglycemic Agents/administration & dosage; Kinetics; Mannitol/chemistry; Nateglinide; Particle Size; Phenylalanine/administration & dosage; Phenylalanine/chemistry; Poloxamer/chemistry; Povidone/chemistry; Silicon Dioxide/chemistry; Solubility; Starch/analogs & derivatives; Starch/chemistry

Key words

Co-milling; Dissolution rate; Hydrophilic swellable polymers; Insoluble drug; Nateglinide; Superdisintegrant

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylalanine / Technology, Pharmaceutical / Cyclohexanes / Hypoglycemic Agents Language: En Journal: Int J Pharm Year: 2013 Document type: Article Affiliation country: Italy Country of publication: Netherlands

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