Acitretin exhibits inhibitory effects towards UDP-glucuronosyltransferase (UGT)1A9-mediated 4-methylumbelliferone (4-MU) and propofol glucuronidation reaction.

Yu, Ming-Lian; Yang, Yue; Wang, Cong-Min; Zhang, Meng-Meng; Bai, Miao-Chun; Guo, Yue-Ling

Yu, Ming-Lian; Yang, Yue; Wang, Cong-Min; Zhang, Meng-Meng; Bai, Miao-Chun; Guo, Yue-Ling.

Affiliation

Yu ML; Department of Pharmacy, The Military General Hospital of Beijing PLA, Beijing, China.

Pharmazie ; 68(6): 449-52, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23875253

Subject(s)

Acitretin/pharmacology; Glucuronosyltransferase/antagonists & inhibitors; Hymecromone/metabolism; Keratolytic Agents/pharmacology; Propofol/metabolism; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glucuronides/metabolism; Glucuronosyltransferase/metabolism; Humans; In Vitro Techniques; Isoenzymes/metabolism; Kinetics; Liver/enzymology; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; UDP-Glucuronosyltransferase 1A9

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Collection: 01-internacional Database: MEDLINE Main subject: Hymecromone / Propofol / Glucuronosyltransferase / Acitretin / Keratolytic Agents Limits: Humans Language: En Journal: Pharmazie Journal subject: FARMACIA Year: 2013 Document type: Article Affiliation country: China Country of publication: Germany

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