Integrative genomic analysis of the human immune response to influenza vaccination.
Elife
; 2: e00299, 2013 Jul 16.
Article
in En
| MEDLINE
| ID: mdl-23878721
ABSTRACT
Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits. DOIhttp//dx.doi.org/10.7554/eLife.00299.001.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Influenza B virus
/
Influenza Vaccines
/
Vaccination
/
Genomics
/
Influenza, Human
/
Influenza A Virus, H1N1 Subtype
/
Influenza A Virus, H3N2 Subtype
/
Immunity, Humoral
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Elife
Year:
2013
Document type:
Article
Affiliation country:
United States