Elevated antigen-specific Th2 type response is associated with the poor prognosis of hand, foot and mouth disease.
Virus Res
; 177(1): 62-5, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-23886670
ABSTRACT
The immunopathogenesis of severe hand, foot and mouth disease (HFMD) remains elusive. This study revealed that enterovirus 71 (EV71) epitope-specific CD4+ T cell responses of HFMD patients were skewed toward a Th2 cytokine profile. Patients that demonstrated higher levels of IL-4 expression in their CD4 T cells following antigen stimulation in vitro tended to have a more prolonged period of high fevers and a longer duration of illness. Thus, an increase of EV71 epitope-specific Th2 type response may portend the poor prognosis for some HFMD patients.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Th2 Cells
/
Enterovirus A, Human
/
Hand, Foot and Mouth Disease
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Virus Res
Journal subject:
VIROLOGIA
Year:
2013
Document type:
Article
Affiliation country:
China