Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis.

Kim, Jean; Kim, Tae-Youn; Cho, Kyung-Sook; Kim, Ha Na; Koh, Jae-Young

Kim, Jean; Kim, Tae-Youn; Cho, Kyung-Sook; Kim, Ha Na; Koh, Jae-Young.

Affiliation

Kim J; Neural Injury Research Lab, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.

Neurobiol Dis ; 59: 80-5, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23891729

Subject(s)

Amyotrophic Lateral Sclerosis/drug therapy; Autophagy/drug effects; Neuroprotective Agents/therapeutic use; Progesterone/therapeutic use; Amyotrophic Lateral Sclerosis/genetics; Amyotrophic Lateral Sclerosis/pathology; Amyotrophic Lateral Sclerosis/physiopathology; Animals; Animals, Newborn; Astrocytes/drug effects; Cell Count; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors/pharmacology; Humans; In Vitro Techniques; Male; Mice; Mice, Transgenic; Motor Activity/drug effects; Motor Activity/genetics; Motor Neurons/drug effects; Spinal Cord/cytology; Superoxide Dismutase/genetics; Survival Analysis; Time Factors; Transcription Factor TFIIH; Transcription Factors/metabolism

Key words

ALS; LC3; Spinal cord; Steroid hormone; hSOD1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Progesterone / Autophagy / Neuroprotective Agents / Amyotrophic Lateral Sclerosis Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2013 Document type: Article Country of publication: United States

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