Galanin stimulates neurite outgrowth from sensory neurons by inhibition of Cdc42 and Rho GTPases and activation of cofilin.

Hobson, Sally-Ann; Vanderplank, Penny A; Pope, Robert J P; Kerr, Niall C H; Wynick, David

Hobson, Sally-Ann; Vanderplank, Penny A; Pope, Robert J P; Kerr, Niall C H; Wynick, David.

Affiliation

Hobson SA; Schools of Physiology and Pharmacology and Clinical Sciences, University of Bristol, Bristol, UK.

J Neurochem ; 127(2): 199-208, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23895321

Subject(s)

Actin Depolymerizing Factors/physiology; Galanin/pharmacology; Neurites/drug effects; Sensory Receptor Cells/drug effects; cdc42 GTP-Binding Protein/antagonists & inhibitors; rho GTP-Binding Proteins/antagonists & inhibitors; Animals; Blotting, Western; Enzyme Activation/drug effects; Female; Ganglia, Spinal/cytology; Growth Cones/drug effects; Mice; Mice, Knockout; Microscopy, Video; PC12 Cells; Pseudopodia/drug effects; Rats; Stimulation, Chemical; rac GTP-Binding Proteins/metabolism

Key words

Cdc42; DRG; Rho; cofilin; galanin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sensory Receptor Cells / Neurites / Galanin / Rho GTP-Binding Proteins / Cdc42 GTP-Binding Protein / Actin Depolymerizing Factors Limits: Animals Language: En Journal: J Neurochem Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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