Recent contributions from the asymmetric aza-Michael reaction to alkaloids total synthesis.
Nat Prod Rep
; 30(9): 1211-25, 2013 Sep.
Article
in En
| MEDLINE
| ID: mdl-23896828
ABSTRACT
This review focuses on recent applications of the aza-Michael reaction in alkaloids total synthesis with a special emphasis on stereoselectivity. The report highlights achievements and challenges over the past five years and describes stereoselective intra- and inter-molecular conjugate addition of nitrogen-containing nucleophiles, including tandem and cascade processes. Total asymmetric syntheses of natural scaffolds, such as pyrrolidine, piperidine and "izidine" families, are depicted. Multi-step syntheses of highly challenging natural products are further detailed, assessing the scope of the stereocontrolled aza-Michael reaction as a powerful tool in alkaloid chemistry.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biological Products
/
Alkaloids
Language:
En
Journal:
Nat Prod Rep
Journal subject:
QUIMICA
Year:
2013
Document type:
Article
Affiliation country:
France