ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain.

Wainwright, Shane D; Bondeson, Jan; Caterson, Bruce; Hughes, Clare E

Wainwright, Shane D; Bondeson, Jan; Caterson, Bruce; Hughes, Clare E.

Affiliation

Wainwright SD; Cardiff University, Cardiff, UK.

Arthritis Rheum ; 65(11): 2866-75, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23897278

Subject(s)

ADAM Proteins/genetics; ADAM Proteins/metabolism; Aggrecans/metabolism; Alternative Splicing/genetics; Osteoarthritis/genetics; Osteoarthritis/metabolism; Procollagen N-Endopeptidase/genetics; Procollagen N-Endopeptidase/metabolism; ADAM Proteins/immunology; ADAMTS4 Protein; Aggrecans/chemistry; Autoantibodies/immunology; Cells, Cultured; Coculture Techniques; HEK293 Cells; Humans; Osteoarthritis/immunology; Procollagen N-Endopeptidase/immunology; Protein Structure, Tertiary; RNA, Messenger/genetics; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Substrate Specificity; Synovial Membrane/cytology; Synovial Membrane/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Procollagen N-Endopeptidase / Alternative Splicing / ADAM Proteins / Aggrecans Limits: Humans Language: En Journal: Arthritis Rheum Year: 2013 Document type: Article Affiliation country: United kingdom

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