Correlation of immunohistopathological expression of somatostatin receptor-2 in breast cancer and tumor detection with 68Ga-DOTATOC and 18F-FDG PET imaging in an animal model.
Anticancer Res
; 33(8): 3015-9, 2013 Aug.
Article
in En
| MEDLINE
| ID: mdl-23898054
ABSTRACT
BACKGROUND:
Fludeoxyglucose positron emission topography ((18)F-FDG PET) is insufficiently sensitive at detecting small or low-grade breast tumors. The characterization of somatostatin receptors (SSTR) in tumors and the development of (68)Ga-DOTATOC PET for imaging could be of interest. The aim of this study was to validate an animal model expressing SSTR2 and to correlate the immunohistochemical (IHC) analysis with (18)F-FDG and (68)Ga-DOTATOC uptake in vivo. MATERIALS ANDMETHODS:
Ten nude mice were xenografted with the ZR-75-1 breast tumor cell line. Imaging was performed with (68)Ga-DOTATOC and (18)F-FDG and correlated to IHC analysis of SSTR2.RESULTS:
IHC analyses showed that the tumors expressed SSTR2. On PET imaging, the tumors were barely visible with (18)F-FDG, whereas with (68)Ga-DOTATOC, specific two-fold higher uptake was observed (p<0.005).CONCLUSION:
Our results suggest that (68)Ga-DOTATOC PET could be used for detection of breast tumors not detected with (18)F-FDG. SSTR2 status should be assessed to allow for individual treatment.Key words
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organometallic Compounds
/
Octreotide
/
Mammary Neoplasms, Animal
/
Receptors, Somatostatin
/
Fluorodeoxyglucose F18
/
Positron-Emission Tomography
Type of study:
Diagnostic_studies
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Anticancer Res
Year:
2013
Document type:
Article
Affiliation country:
France