Peripheral contribution of NGF and ASIC1a to colonic hypersensitivity in a rat model of irritable bowel syndrome.

Matricon, J; Muller, E; Accarie, A; Meleine, M; Etienne, M; Voilley, N; Busserolles, J; Eschalier, A; Lazdunski, M; Bourdu, S; Gelot, A; Ardid, D

Matricon, J; Muller, E; Accarie, A; Meleine, M; Etienne, M; Voilley, N; Busserolles, J; Eschalier, A; Lazdunski, M; Bourdu, S; Gelot, A; Ardid, D.

Affiliation

Matricon J; NEURO-DOL, Pharmacologie Fondamentale et Clinique de la Douleur, Faculté de Médecine, INSERM/UdA, UMR 1107, Université d'Auvergne, Clermont-Ferrand, France.

Neurogastroenterol Motil ; 25(11): e740-54, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23902154

Subject(s)

Acid Sensing Ion Channels/metabolism; Ganglia, Spinal/metabolism; Hyperalgesia/etiology; Irritable Bowel Syndrome/metabolism; Nerve Growth Factor/metabolism; Acid Sensing Ion Channel Blockers/pharmacology; Amiloride/pharmacology; Animals; Disease Models, Animal; Ganglia, Spinal/drug effects; Hyperalgesia/metabolism; Hyperalgesia/physiopathology; Irritable Bowel Syndrome/physiopathology; Male; Nerve Growth Factor/pharmacology; Pain Measurement; Rats; Rats, Sprague-Dawley

Key words

acid-sensing ion channel; animal model; colonic hypersensitivity; nerve growth factor; sensory neurons

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nerve Growth Factor / Irritable Bowel Syndrome / Acid Sensing Ion Channels / Ganglia, Spinal / Hyperalgesia Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurogastroenterol Motil Journal subject: GASTROENTEROLOGIA / NEUROLOGIA Year: 2013 Document type: Article Affiliation country: France Country of publication: United kingdom

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