Small airway deposition of dornase alfa during exacerbations in cystic fibrosis; a randomized controlled clinical trial.

Bakker, E M; Volpi, S; Salonini, E; Müllinger, B; Kroneberg, P; Bakker, M; Hop, W C J; Assael, B M; Tiddens, H A W M

Bakker, E M; Volpi, S; Salonini, E; Müllinger, B; Kroneberg, P; Bakker, M; Hop, W C J; Assael, B M; Tiddens, H A W M.

Affiliation

Bakker EM; Department of Paediatric Pulmonology and Allergology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

Pediatr Pulmonol ; 49(2): 154-61, 2014 Feb.

Article in En | MEDLINE | ID: mdl-23913868

Subject(s)

Cystic Fibrosis/drug therapy; Deoxyribonuclease I/administration & dosage; Expectorants/administration & dosage; Nebulizers and Vaporizers; Administration, Inhalation; Adolescent; Adult; Aerosols; Child; Cystic Fibrosis/physiopathology; Deoxyribonuclease I/therapeutic use; Disease Progression; Double-Blind Method; Expectorants/therapeutic use; Female; Forced Expiratory Volume; Humans; Intention to Treat Analysis; Male; Middle Aged; Recombinant Proteins/administration & dosage; Recombinant Proteins/therapeutic use; Spirometry; Treatment Outcome; Vital Capacity; Young Adult

Key words

aerosol; nebulizer; nocturnal oxygen saturation; respiratory tract exacerbation; spirometry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nebulizers and Vaporizers / Cystic Fibrosis / Deoxyribonuclease I / Expectorants Type of study: Clinical_trials Limits: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Language: En Journal: Pediatr Pulmonol Journal subject: PEDIATRIA Year: 2014 Document type: Article Affiliation country: Netherlands Country of publication: United States

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