Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice.

Reber, Laurent L; Marichal, Thomas; Mukai, Kaori; Kita, Yoshihiro; Tokuoka, Suzumi M; Roers, Axel; Hartmann, Karin; Karasuyama, Hajime; Nadeau, Kari C; Tsai, Mindy; Galli, Stephen J

Reber, Laurent L; Marichal, Thomas; Mukai, Kaori; Kita, Yoshihiro; Tokuoka, Suzumi M; Roers, Axel; Hartmann, Karin; Karasuyama, Hajime; Nadeau, Kari C; Tsai, Mindy; Galli, Stephen J.

Affiliation

Reber LL; Department of Pathology, Stanford University School of Medicine, Stanford, Calif.

J Allergy Clin Immunol ; 132(4): 881-8.e1-11, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23915716

Subject(s)

Anaphylaxis/immunology; Arachis/immunology; Basophils/immunology; Diphtheria Toxin/immunology; Mast Cells/immunology; Peanut Hypersensitivity/complications; Peanut Hypersensitivity/immunology; Anaphylaxis/etiology; Anaphylaxis/metabolism; Animals; Antibodies/immunology; Antibodies/metabolism; Basophils/metabolism; Mast Cells/metabolism; Mice; Mice, Inbred C57BL; Mutation; Peanut Hypersensitivity/metabolism; Proto-Oncogene Proteins c-kit/immunology; Proto-Oncogene Proteins c-kit/metabolism

Key words

BMCMC; Bone marrowderived cultured mast cell; CTMC; Carboxypeptidase A3; Connective tissuetype mast cells; Cpa3; DT; DTR; Diphtheria toxin; Diphtheria toxin receptor; Kit(W-sh/W-sh); MC; MMC; Mast cell; Mast cell protease; Mcpt; Mucosal mast cell; PAF; PIA; PSA; Passive systemic anaphylaxis; Peanut; Peanut-induced anaphylaxis; Platelet-activating factor; WT; Wild-type; allergy; anaphylaxis; basophils; carboxypeptidase A3; diphtheria toxin; mast cell protease 5; mast cells; neutrophils

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arachis / Basophils / Peanut Hypersensitivity / Diphtheria Toxin / Anaphylaxis / Mast Cells Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Allergy Clin Immunol Year: 2013 Document type: Article Country of publication: United States

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