Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance.

Ellegaard, Anne-Marie; Groth-Pedersen, Line; Oorschot, Viola; Klumperman, Judith; Kirkegaard, Thomas; Nylandsted, Jesper; Jäättelä, Marja

Ellegaard, Anne-Marie; Groth-Pedersen, Line; Oorschot, Viola; Klumperman, Judith; Kirkegaard, Thomas; Nylandsted, Jesper; Jäättelä, Marja.

Affiliation

Ellegaard AM; Corresponding Author: Marja Jäättelä, Cell Death and Metabolism, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark. mj@cancer.dk.

Mol Cancer Ther ; 12(10): 2018-30, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23920274

Subject(s)

Drug Resistance, Neoplasm/drug effects; Indoles/administration & dosage; Neoplasms/drug therapy; Pyrroles/administration & dosage; Apoptosis/drug effects; Cell Survival/drug effects; HeLa Cells; Humans; Lysosomes/drug effects; MCF-7 Cells; Neoplasms/genetics; Neoplasms/pathology; Sphingomyelin Phosphodiesterase/antagonists & inhibitors; Sunitinib

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Drug Resistance, Neoplasm / Indoles / Neoplasms Limits: Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2013 Document type: Article Affiliation country: Denmark Country of publication: United States

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