Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity.
Neonatology
; 104(3): 161-7, 2013.
Article
in En
| MEDLINE
| ID: mdl-23921508
ABSTRACT
BACKGROUND:
Interleukin-6 (IL-6) signalling involves the interplay between IL-6, soluble IL-6 receptor (sIL-6R) and soluble gp130 (sgp130). IL-6 activity is modulated by the soluble receptors to produce both pro- and anti-inflammatory effects in human diseases and animal models. The expression and functional activity of these molecules in lungs of preterm ventilated infants is unknown.OBJECTIVES:
We investigated this pathway in preterm infants who were at risk of developing chronic lung disease of prematurity (CLD).METHODS:
Cytokines and soluble receptors were measured in bronchoalveolar lavage fluid (BALF) from ventilated preterm infants ≤32 weeks of gestation who did or did not develop CLD. B9 cells, which specifically proliferate to IL-6, were used to assess BALF IL-6 functional activity.RESULTS:
Inflammatory cells, IL-8 and monocyte chemotactic protein-1 were increased in BALF from the CLD group when compared to the No CLD group (p < 0.05). BALF IL-6 and sIL-6R were similar in both groups. In contrast, BALF sgp130 and sgp130/sIL-6R were greater in the CLD group when compared to the No CLD group (p = 0.01 and p = 0.02, respectively). However, the increased BALF sgp130 did not appear to modulate the BALF IL-6 functional activity.CONCLUSION:
Lung inflammation was observed in the CLD group. Increased BALF sgp130 was noted in the CLD group but it did not appear to modulate the pulmonary IL-6 bioactivity. Further research is needed to investigate the potential modulatory activity of sgp130 in the preterm lung.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bronchopulmonary Dysplasia
/
Infant, Premature
/
Interleukin-6
/
Chemokine CCL2
/
Receptors, Interleukin-6
/
Cytokine Receptor gp130
Type of study:
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
Neonatology
Journal subject:
PERINATOLOGIA
Year:
2013
Document type:
Article
Affiliation country:
United kingdom