State-dependent effects of prefrontal repetitive transcranial magnetic stimulation on emotional working memory.
Brain Stimul
; 6(6): 905-12, 2013 Nov.
Article
in En
| MEDLINE
| ID: mdl-23928102
BACKGROUND: A growing body of findings illustrates the importance of state-dependency in studies using brain stimulation. OBJECTIVE: We aimed to investigate the effects of tDCS priming followed by rTMS applied over the right dorsolateral prefrontal cortex (DLPFC) on emotional working memory. METHODS: In a randomized single-blind within-subjects design, participants performed an emotional 3-back task at baseline and after tDCS priming (anodal, cathodal) and subsequent low-frequency rTMS (active, sham) of the right DLPFC. Stimuli consisted of words related to the distinct emotion categories fear and anger as well as neutral words. RESULTS: Task accuracy increased for fear-related words and decreased for neutral words across stimulation conditions. No general state-dependent effects of prefrontal rTMS on working memory were found. We further showed a detrimental effect of negative emotional content on working memory performance. CONCLUSIONS: Our findings support a hemispheric lateralization of emotion processing by demonstrating that the withdrawal-related emotion fear is associated with the right DLPFC and contribute to clarifying the interaction between working memory and emotion.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prefrontal Cortex
/
Emotions
/
Transcranial Magnetic Stimulation
/
Functional Laterality
/
Memory, Short-Term
Type of study:
Clinical_trials
Limits:
Adult
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Female
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Humans
/
Male
Language:
En
Journal:
Brain Stimul
Journal subject:
CEREBRO
Year:
2013
Document type:
Article
Country of publication:
United States