Hypercholesterolemia in pregnant mice increases the susceptibility to atherosclerosis in adult life.
Vascular
; 22(5): 328-35, 2014 Oct.
Article
in En
| MEDLINE
| ID: mdl-23929425
ABSTRACT
PURPOSE:
To determine the effects of hypercholesterolemia in pregnant mice on the susceptibility to atherosclerosis in adult life through a new animal modeling approach.METHODS:
Male offspring from apoE-/- mice fed with regular (R) or high (H) cholesterol chow during pregnancy were randomly subjected to regular (Groups R-R and H-R, n = 10) or high cholesterol diet (Groups R-H and H-H, n = 10) for 14 weeks. Plasma lipid profiles were determined in all rats. The abdominal aorta was examined for the severity of atherosclerotic lesions in offspring.RESULTS:
Lipids significantly increased while high-density lipoprotein-cholesterol/low-density lipoprotein-cholesterol decreased in mothers fed high cholesterol chow after delivery compared with before pregnancy (p < 0.01). Groups R-H and H-R indicated dyslipidemia and significant atherosclerotic lesions. Group H-H demonstrated the highest lipids, lowest high-density lipoprotein-cholesterol/low-density lipoprotein-cholesterol, highest incidence (90%), plaque area to luminal area ratio (0.78 ± 0.02) and intima to media ratio (1.57 ± 0.05).CONCLUSION:
Hypercholesterolemia in pregnant mice may increase susceptibility to atherosclerosis in their adult offspring.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aorta, Abdominal
/
Disease Susceptibility
/
Atherosclerosis
/
Hypercholesterolemia
/
Lipids
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Vascular
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
2014
Document type:
Article
Affiliation country:
China