Aldehydes/pharmacology; Cytoprotection/drug effects; Docosahexaenoic Acids/chemistry; Endothelial Cells/cytology; Endothelial Cells/metabolism; NF-E2-Related Factor 2/metabolism; Adaptor Proteins, Signal Transducing/metabolism; Aldehydes/metabolism; Animals; Antioxidants/pharmacology; Aorta/drug effects; Aorta/physiology; Body Weight/drug effects; DNA Damage; Diet; Eicosapentaenoic Acid/chemistry; Endothelial Cells/drug effects; Gene Expression Regulation/drug effects; Glutamate-Cysteine Ligase/metabolism; Heme Oxygenase-1/metabolism; Human Umbilical Vein Endothelial Cells/cytology; Human Umbilical Vein Endothelial Cells/drug effects; Human Umbilical Vein Endothelial Cells/enzymology; Humans; Lipid Peroxidation/drug effects; Male; Mice; Oxidation-Reduction/drug effects; Oxidative Stress/drug effects; Reactive Oxygen Species/metabolism; Sequestosome-1 Protein; Vasodilation/drug effects