Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode.

Lee, Sang Jae; Han, Byeong-Gu; Cho, Jea-Won; Choi, Jang-Sik; Lee, Jaekyoo; Song, Ho-Juhn; Koh, Jong Sung; Lee, Byung Il

Lee, Sang Jae; Han, Byeong-Gu; Cho, Jea-Won; Choi, Jang-Sik; Lee, Jaekyoo; Song, Ho-Juhn; Koh, Jong Sung; Lee, Byung Il.

Affiliation

Lee SJ; Biomolecular Function Research Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi, Republic of Korea.

PLoS One ; 8(7): e70358, 2013.

Article in En | MEDLINE | ID: mdl-23936194

Subject(s)

Protein Kinase Inhibitors/chemistry; Protein Structure, Tertiary; Proto-Oncogene Proteins c-pim-1/chemistry; Pyrimidines/chemistry; Binding Sites; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; Protein Binding; Protein Kinase Inhibitors/metabolism; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins c-pim-1/antagonists & inhibitors; Proto-Oncogene Proteins c-pim-1/metabolism; Pyridones/chemistry; Pyridones/metabolism; Pyridones/pharmacology; Pyrimidines/metabolism; Pyrimidines/pharmacology; Substrate Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Protein Structure, Tertiary / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-pim-1 Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Country of publication: United States

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