Novel WWP2 ubiquitin ligase isoforms as potential prognostic markers and molecular targets in cancer.

Soond, Surinder M; Smith, Paul G; Wahl, Lloyd; Swingler, Tracey E; Clark, Ian M; Hemmings, Andrew M; Chantry, Andrew

Soond, Surinder M; Smith, Paul G; Wahl, Lloyd; Swingler, Tracey E; Clark, Ian M; Hemmings, Andrew M; Chantry, Andrew.

Affiliation

Soond SM; School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.

Biochim Biophys Acta ; 1832(12): 2127-35, 2013 Dec.

Article in En | MEDLINE | ID: mdl-23938591

Subject(s)

Biomarkers, Tumor/metabolism; Breast Neoplasms/metabolism; Epithelial-Mesenchymal Transition; Melanoma/metabolism; Prostatic Neoplasms/metabolism; Ubiquitin-Protein Ligases/metabolism; Apoptosis; Blotting, Western; Breast Neoplasms/pathology; Case-Control Studies; Cell Proliferation; Female; Gene Expression Profiling; Humans; Immunoprecipitation; Luciferases/metabolism; Male; Melanoma/pathology; Neoplasm Staging; Oligonucleotide Array Sequence Analysis; Prognosis; Prostatic Neoplasms/pathology; Protein Isoforms; RNA, Small Interfering/genetics; Smad3 Protein/metabolism; Transforming Growth Factor beta/metabolism; Tumor Cells, Cultured; Ubiquitin-Protein Ligases/antagonists & inhibitors; Ubiquitin-Protein Ligases/genetics

Key words

Cancer; EMT; Smads; TGFß; Transcription; Ubiquitin ligase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Breast Neoplasms / Biomarkers, Tumor / Ubiquitin-Protein Ligases / Epithelial-Mesenchymal Transition / Melanoma Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Biochim Biophys Acta Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: Netherlands

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