Bacterial Proteins/physiology; Cardiovascular Diseases/genetics; Deoxyribonucleases, Type II Site-Specific/physiology; Deoxyribonucleases/physiology; Genetic Engineering/methods; Genomics; Induced Pluripotent Stem Cells/cytology; Mutagenesis, Site-Directed/methods; Precision Medicine/trends; Xanthomonas/enzymology; Animals; Bacterial Proteins/genetics; Binding Sites; Cardiovascular Diseases/therapy; Cell Differentiation; Cells, Cultured/cytology; Cells, Cultured/transplantation; DNA/genetics; DNA/metabolism; Deoxyribonucleases/genetics; Deoxyribonucleases, Type II Site-Specific/genetics; Forecasting; Genes, Reporter; Genetic Engineering/trends; Humans; Induced Pluripotent Stem Cells/transplantation; Models, Cardiovascular; Models, Genetic; Protein Structure, Tertiary; Recombinant Fusion Proteins/physiology; Recombinational DNA Repair; Substrate Specificity; Xanthomonas axonopodis/enzymology; Zebrafish/genetics

TALENs; cardiovascular disease modeling; genome engineering; induced pluripotent stem cells; zebrafish