Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6R&#945; signaling.

Gruber, Sabine; Straub, Beate K; Ackermann, P Justus; Wunderlich, Claudia M; Mauer, Jan; Seeger, Jens M; Büning, Hildegard; Heukamp, Lukas; Kashkar, Hamid; Schirmacher, Peter; Brüning, Jens C; Wunderlich, F Thomas

Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signaling.

Gruber, Sabine; Straub, Beate K; Ackermann, P Justus; Wunderlich, Claudia M; Mauer, Jan; Seeger, Jens M; Büning, Hildegard; Heukamp, Lukas; Kashkar, Hamid; Schirmacher, Peter; Brüning, Jens C; Wunderlich, F Thomas.

Affiliation

Gruber S; Max Planck Institute for Neurological Research Cologne, Institute for Genetics, University of Cologne, 50937 Cologne, Germany.

Cell Rep ; 4(4): 669-80, 2013 Aug 29.

Article in En | MEDLINE | ID: mdl-23954788

Subject(s)

Carcinogenesis/metabolism; Liver Neoplasms, Experimental/etiology; Liver Neoplasms, Experimental/metabolism; Myeloid Cell Leukemia Sequence 1 Protein/metabolism; Obesity/complications; Receptors, Interleukin-6/metabolism; Animals; Apoptosis; Glycogen Synthase Kinase 3/metabolism; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Hepatocytes/metabolism; Humans; Liver Neoplasms, Experimental/pathology; Mice; Mice, Knockout; Obesity/metabolism; Protein Phosphatase 1/genetics; Protein Phosphatase 1/metabolism; Protein Stability; Receptors, Interleukin-6/genetics; Signal Transduction; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Interleukin-6 / Carcinogenesis / Myeloid Cell Leukemia Sequence 1 Protein / Liver Neoplasms, Experimental / Obesity Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2013 Document type: Article Affiliation country: Germany Country of publication: United States

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