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Waol A, trans-dihydrowaol A, and cis-dihydrowaol A: polyketide-derived γ-lactones from a Volutella species.
El-Elimat, Tamam; Figueroa, Mario; Raja, Huzefa A; Adcock, Audrey F; Kroll, David J; Swanson, Steven M; Wani, Mansukh C; Pearce, Cedric J; Oberlies, Nicholas H.
Affiliation
  • El-Elimat T; University of North Carolina at Greensboro, Department of Chemistry and Biochemistry, Greensboro, NC 27402, United States.
Tetrahedron Lett ; 54(32): 4300-4302, 2013 Aug 07.
Article in En | MEDLINE | ID: mdl-23956472
An organic extract of a filamentous fungus (MSX 58801), identified as a Volutella sp. (Hypocreales, Ascomycota), displayed moderate cytotoxic activity against NCI-H460 human large cell lung carcinoma. Bioactivity-directed fractionation led to the isolation of three γ-lactones having the furo[3,4-b]pyran-5-one bicyclic ring system [waol A (1), trans-dihydrowaol A (2), and cis-dihydrowaol A (3)]. The structures were elucidated using a set of spectroscopic and spectrometric techniques; the absolute configuration of 2 was established via a modified Mosher's ester method. Compounds 1 and 2 were evaluated for cytotoxicity against a human cancer cell panel.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Tetrahedron Lett Year: 2013 Document type: Article Affiliation country: United States Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Tetrahedron Lett Year: 2013 Document type: Article Affiliation country: United States Country of publication: United kingdom