Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study.

Wang, Qun; Zhong, Yan-Jun; Yuan, Jing-Ping; Shao, Li-Hua; Zhang, Jue; Tang, Li; Liu, Shao-Ping; Hong, Ya-Ping; Firestone, Raymond A; Li, Yan

Wang, Qun; Zhong, Yan-Jun; Yuan, Jing-Ping; Shao, Li-Hua; Zhang, Jue; Tang, Li; Liu, Shao-Ping; Hong, Ya-Ping; Firestone, Raymond A; Li, Yan.

Affiliation

Wang Q; Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, No 169 Donghu Road, Wuchang District, 430071 Wuhan, P,R, China. liyansd2@163.com.

J Transl Med ; 11: 192, 2013 Aug 21.

Article in En | MEDLINE | ID: mdl-23961994

Subject(s)

Carcinoma, Hepatocellular/drug therapy; Doxorubicin/analogs & derivatives; Doxorubicin/therapeutic use; Liver Neoplasms/drug therapy; Lung Neoplasms/secondary; Oligopeptides/adverse effects; Oligopeptides/therapeutic use; Prodrugs/therapeutic use; Animals; Carcinoma, Hepatocellular/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; Doxorubicin/adverse effects; Doxorubicin/pharmacology; Drug Evaluation, Preclinical; Extracellular Signal-Regulated MAP Kinases/metabolism; Hematologic Tests; Humans; Immunohistochemistry; Liver Neoplasms/pathology; Lung Neoplasms/drug therapy; Lung Neoplasms/pathology; MAP Kinase Signaling System/drug effects; Male; Mice; Mice, Nude; Oligopeptides/pharmacology; Prodrugs/adverse effects; Prodrugs/pharmacology

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Prodrugs / Doxorubicin / Carcinoma, Hepatocellular / Liver Neoplasms / Lung Neoplasms Type of study: Clinical_trials Limits: Animals / Humans / Male Language: En Journal: J Transl Med Year: 2013 Document type: Article Affiliation country: China Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google