Increased ratio of glutamate/glutamine to creatine in the right hippocampus contributes to depressive symptoms in patients with epilepsy.
Epilepsy Behav
; 29(1): 144-9, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-23969202
ABSTRACT
PURPOSE:
Our study aimed to investigate whether the glutamatergic system in the hippocampus is correlated with depressive symptoms in patients with epilepsy.METHODS:
Fifty patients with epilepsy were recruited and divided into three groups on the basis of their Hamilton Depression Rating Scale (HAMD) scores. Single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) was carried out. Pearson correlation analysis and multiple linear regression analysis were performed to investigate any correlation between the variables of hippocampal metabolites and HAMD scores.RESULTS:
Proton magnetic resonance spectroscopy analysis showed that the ratio of glutamate/glutamine to creatine (Glx/Cr) in the right hippocampus was significantly increased in patients with moderate depression and correlated positively with HAMD scores. Multiple linear regression analysis showed that the ratio of Glx/Cr in the right hippocampus was an independent risk factor relating to depressive symptoms in patients with epilepsy.CONCLUSION:
A disturbance of the hippocampal glutamatergic system may be involved in the pathogenesis of depression in epilepsy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glutamic Acid
/
Creatine
/
Depression
/
Glutamine
/
Hippocampus
/
Functional Laterality
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Epilepsy Behav
Journal subject:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Year:
2013
Document type:
Article
Affiliation country:
China