The interdependence of antibody C and V regions on specificity and affinity: significant implications for the engineering of therapeutic antibodies.

Nosanchuk, Joshua D

Nosanchuk, Joshua D.

Virulence ; 4(6): 439-40, 2013 Aug 15.

Article in En | MEDLINE | ID: mdl-23979029

Subject(s)

Antibodies/genetics; Immunoglobulin Constant Regions/genetics; Immunoglobulin Variable Region/genetics; Animals; Antibodies/chemistry; Antibodies/immunology; Antibodies/therapeutic use; Antibody Specificity; Drug Therapy; Humans; Immunoglobulin Constant Regions/immunology; Immunoglobulin Constant Regions/therapeutic use; Immunoglobulin Variable Region/immunology; Immunoglobulin Variable Region/therapeutic use; Mice; Protein Engineering

Key words

Bacillus anthracis; C region; V region; antibody; isotope; therapeutics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Variable Region / Immunoglobulin Constant Regions / Antibodies Limits: Animals / Humans Language: En Journal: Virulence Year: 2013 Document type: Article Country of publication: United States

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