Genetic variations in toll-like receptor pathway and lung function decline in Cystic fibrosis patients.

Haerynck, F; Mahachie John, J M; Van Steen, K; Schelstraete, P; Van daele, S; Loeys, B; Van Thielen, M; De Canck, I; Nuytinck, L; De Baets, F

Haerynck, F; Mahachie John, J M; Van Steen, K; Schelstraete, P; Van daele, S; Loeys, B; Van Thielen, M; De Canck, I; Nuytinck, L; De Baets, F.

Affiliation

Haerynck F; Department of Pediatric Pulmonology and Immunology, Ghent University Hospital Ghent, Gent, Belgium. Electronic address: filomeen.haerynck@ugent.be.

Hum Immunol ; 74(12): 1649-55, 2013 Dec.

Article in En | MEDLINE | ID: mdl-23994582

Subject(s)

Cystic Fibrosis/genetics; Cystic Fibrosis/physiopathology; Forced Expiratory Volume; Polymorphism, Single Nucleotide; Toll-Like Receptors/genetics; Adolescent; Adult; Alleles; Case-Control Studies; Child; Child, Preschool; Cystic Fibrosis/metabolism; Cystic Fibrosis Transmembrane Conductance Regulator/genetics; Female; Genetic Association Studies; Humans; Male; Phenotype; Signal Transduction; Toll-Like Receptors/metabolism; Young Adult

Key words

CF; FEV1; LBP; NFκB; Pa; Pseudomonas aeruginosa; SNP; TLR; cystic fibrosis; forced expiratory volume in one second; lipopolysaccharide binding protein; nuclear factor kappa beta; single nucleotide polymorphisms; toll-like receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Forced Expiratory Volume / Polymorphism, Single Nucleotide / Cystic Fibrosis / Toll-Like Receptors Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Language: En Journal: Hum Immunol Year: 2013 Document type: Article Country of publication: United States

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