Oxidative stress in cardiomyocytes contributes to decreased SERCA2a activity in rats with metabolic syndrome.

Balderas-Villalobos, Jaime; Molina-Muñoz, Tzindilu; Mailloux-Salinas, Patrick; Bravo, Guadalupe; Carvajal, Karla; Gómez-Viquez, Norma L

Balderas-Villalobos, Jaime; Molina-Muñoz, Tzindilu; Mailloux-Salinas, Patrick; Bravo, Guadalupe; Carvajal, Karla; Gómez-Viquez, Norma L.

Affiliation

Balderas-Villalobos J; Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico; and.

Am J Physiol Heart Circ Physiol ; 305(9): H1344-53, 2013 Nov 01.

Article in En | MEDLINE | ID: mdl-23997093

Subject(s)

Metabolic Syndrome/enzymology; Myocytes, Cardiac/enzymology; Oxidative Stress; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism; Animals; Antioxidants/pharmacology; Calcium/metabolism; Calcium Signaling; Calcium-Binding Proteins/metabolism; Dietary Sucrose; Disease Models, Animal; Down-Regulation; Hyperinsulinism/blood; Hyperinsulinism/enzymology; Hypertriglyceridemia/blood; Hypertriglyceridemia/enzymology; Insulin Resistance; Male; Metabolic Syndrome/blood; Metabolic Syndrome/chemically induced; Myocytes, Cardiac/drug effects; Obesity, Abdominal/blood; Obesity, Abdominal/enzymology; Oxidation-Reduction; Oxidative Stress/drug effects; Phosphorylation; Rats; Rats, Wistar; Reactive Oxygen Species/metabolism; Ventricular Dysfunction, Left/enzymology; Ventricular Dysfunction, Left/etiology

Key words

calcium; heart; metabolic syndrome; oxidative stress; sarco(endo)plasmic reticulum Ca2+-ATPase 2a

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Stress / Metabolic Syndrome / Myocytes, Cardiac / Sarcoplasmic Reticulum Calcium-Transporting ATPases Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2013 Document type: Article Country of publication: United States

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