Antenatal administration of vitamin K1: relationship to vitamin K-dependent coagulation factors and incidence rate of periventricular-intraventricular hemorrhage in preterm infants; Egyptian randomized controlled trial.
J Matern Fetal Neonatal Med
; 27(8): 816-20, 2014 May.
Article
in En
| MEDLINE
| ID: mdl-23998788
ABSTRACT
OBJECTIVES:
To determine the effect of maternal antenatal administration of vitamin K1 on activity level of vitamin K-dependent coagulation factors and on the occurrence of periventricular-intraventricular hemorrhage (PIVH).METHODS:
This study was conducted on 90 infants who were classified into; Group A 30 preterm whose mothers received antenatal vitamin K1, Group B 30 preterm whose mothers did not receive antenatal vitamin K1, and Group C 30 healthy full term newborns as a control group. All newborns were subjected to measurement of the activity level of vitamin K-dependent coagulation factors (FII, FVII, FIX and FX). Cranial ultrasound was done on the 1st, 3rd and 7th days of life.RESULTS:
Group B showed significantly lower activity level of FII and FX with higher incidence of PIVH compared with group A. Neonates who developed PIVH by the 7th day in both group A and B had significantly lower activity level of vitamin K-dependent coagulation factors.CONCLUSION:
when antenatal vitamin K1 was given to pregnant women at imminent risk of preterm labor, their preterm neonates were able to achieve a clotting status approaching that of full term neonates and are less liable to develop PIVH.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin K 1
/
Prenatal Exposure Delayed Effects
/
Blood Coagulation Factors
/
Cerebral Hemorrhage
/
Infant, Premature, Diseases
/
Antifibrinolytic Agents
Type of study:
Clinical_trials
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Country/Region as subject:
Africa
Language:
En
Journal:
J Matern Fetal Neonatal Med
Journal subject:
OBSTETRICIA
/
PERINATOLOGIA
Year:
2014
Document type:
Article
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM