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[Immunogenetic aspects of early rheumatoid arthritis].
Vestn Ross Akad Med Nauk ; (4): 36-43, 2013.
Article in Ru | MEDLINE | ID: mdl-24003720
The study is aimed to investigate the distribution of alleles of HLA-DRB1 gene in patients with early rheumatoid arthritis and healthy individuals in Russian population, and evaluate their significance as molecular genetic markers of rheumatoid arthritis predisposition and protection. The association between alleles of HLA-DRB1 genes, antibodies to cyclic citrullinated peptides and IgM rheumatoid factor was also studied. Low and high resolution HLA-DRB1 genotyping were compared. In the cohort of patients with early rheumatoid arthritis, the alleles of HLA-DRB1 gene were found to be markers of rheumatoid arthritis protection/risk, especially in the homozygous state. They determined production of antibodies to cyclic citrullinated peptides but were not associated with rheumatoid factor IgM levels. These findings support different autoimmune mechanisms of rheumatoid arthritis pathogenesis.
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Collection: 01-internacional Database: MEDLINE Main subject: Rheumatic Fever / Autoantibodies / Biomarkers / Genetic Predisposition to Disease / Immunogenetics Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: Ru Journal: Vestn Ross Akad Med Nauk Journal subject: MEDICINA Year: 2013 Document type: Article Country of publication: Russia
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Collection: 01-internacional Database: MEDLINE Main subject: Rheumatic Fever / Autoantibodies / Biomarkers / Genetic Predisposition to Disease / Immunogenetics Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: Ru Journal: Vestn Ross Akad Med Nauk Journal subject: MEDICINA Year: 2013 Document type: Article Country of publication: Russia