Virus antibody survey in different European populations indicates risk association between coxsackievirus B1 and type 1 diabetes.
Diabetes
; 63(2): 655-62, 2014 Feb.
Article
in En
| MEDLINE
| ID: mdl-24009257
ABSTRACT
Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring type-specific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% CI 1.0-2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Enterovirus B, Human
/
Coxsackievirus Infections
/
Diabetes Mellitus, Type 1
/
Antibodies, Viral
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Diabetes
Year:
2014
Document type:
Article
Affiliation country:
Finland