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Systematic identification of trans eQTLs as putative drivers of known disease associations.
Westra, Harm-Jan; Peters, Marjolein J; Esko, Tõnu; Yaghootkar, Hanieh; Schurmann, Claudia; Kettunen, Johannes; Christiansen, Mark W; Fairfax, Benjamin P; Schramm, Katharina; Powell, Joseph E; Zhernakova, Alexandra; Zhernakova, Daria V; Veldink, Jan H; Van den Berg, Leonard H; Karjalainen, Juha; Withoff, Sebo; Uitterlinden, André G; Hofman, Albert; Rivadeneira, Fernando; Hoen, Peter A C 't; Reinmaa, Eva; Fischer, Krista; Nelis, Mari; Milani, Lili; Melzer, David; Ferrucci, Luigi; Singleton, Andrew B; Hernandez, Dena G; Nalls, Michael A; Homuth, Georg; Nauck, Matthias; Radke, Dörte; Völker, Uwe; Perola, Markus; Salomaa, Veikko; Brody, Jennifer; Suchy-Dicey, Astrid; Gharib, Sina A; Enquobahrie, Daniel A; Lumley, Thomas; Montgomery, Grant W; Makino, Seiko; Prokisch, Holger; Herder, Christian; Roden, Michael; Grallert, Harald; Meitinger, Thomas; Strauch, Konstantin; Li, Yang; Jansen, Ritsert C.
Affiliation
  • Westra HJ; Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.
  • Peters MJ; Department of Internal Medicine, Erasmus Medical Centre Rotterdam, the Netherlands.
  • Esko T; The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/Rotterdam, the Netherlands.
  • Yaghootkar H; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.
  • Schurmann C; Genetics of Complex Traits, University of Exeter Medical School, Exeter, EX1 2LU, UK.
  • Kettunen J; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany.
  • Christiansen MW; Institute for Molecular Medicine Finland FIMM, FI-00014 University of Helsinki, Helsinki, Finland.
  • Fairfax BP; Department of Chronic Disease Prevention, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Schramm K; Cardiovascular Health Research Unit, University of Washington, Seattle, WA.
  • Powell JE; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Zhernakova A; Department of Oncology, Cancer and Haematology Centre, Churchill Hospital, Oxford, OX3 7LJ.
  • Zhernakova DV; Institute of Human Genetics, Helmholz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Veldink JH; Institute of Human Genetics, Technical University Munich, Munich, Germany.
  • Van den Berg LH; University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
  • Karjalainen J; The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
  • Withoff S; Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.
  • Uitterlinden AG; Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.
  • Hofman A; Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Rivadeneira F; Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Hoen PAC'; Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.
  • Reinmaa E; Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.
  • Fischer K; Department of Internal Medicine, Erasmus Medical Centre Rotterdam, the Netherlands.
  • Nelis M; The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/Rotterdam, the Netherlands.
  • Milani L; Department of Epidemiology, Erasmus Medical Center Rotterdam, the Netherlands.
  • Melzer D; The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/Rotterdam, the Netherlands.
  • Ferrucci L; Department of Epidemiology, Erasmus Medical Center Rotterdam, the Netherlands.
  • Singleton AB; Department of Internal Medicine, Erasmus Medical Centre Rotterdam, the Netherlands.
  • Hernandez DG; The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/Rotterdam, the Netherlands.
  • Nalls MA; Department of Epidemiology, Erasmus Medical Center Rotterdam, the Netherlands.
  • Homuth G; Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
  • Nauck M; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.
  • Radke D; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.
  • Völker U; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.
  • Perola M; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.
  • Salomaa V; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Barrack Road, Exeter, EX2 5DW, UK.
  • Brody J; Clinical Research Branch, National Institute on Aging NIA-ASTRA Unit, Harbor Hospital, MD, USA.
  • Suchy-Dicey A; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD, USA.
  • Gharib SA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD, USA.
  • Enquobahrie DA; Department of Molecular Neuroscience and Reta Lila Laboratories, Institute of Neurology, UCL, Queen Square House, Queen Square, London WC1N 3BG, UK.
  • Lumley T; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD, USA.
  • Montgomery GW; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany.
  • Makino S; Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
  • Prokisch H; Institute for Community Medicine, University Medicine Greifswald, D-17487 Greifswald, Germany.
  • Herder C; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17487 Greifswald, Germany.
  • Roden M; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.
  • Grallert H; Department of Chronic Disease Prevention, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Meitinger T; Department of Chronic Disease Prevention, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Strauch K; Cardiovascular Health Research Unit, University of Washington, Seattle, WA.
  • Li Y; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Jansen RC; Computational Medicine Core, Center for Lung Biology, Division of Pulmonary & Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
Nat Genet ; 45(10): 1238-1243, 2013 Oct.
Article in En | MEDLINE | ID: mdl-24013639
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Quantitative Trait Loci Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2013 Document type: Article Affiliation country: Netherlands Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Quantitative Trait Loci Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2013 Document type: Article Affiliation country: Netherlands Country of publication: United States