Combination metronomic oral topotecan and pazopanib: a pharmacokinetic study in patients with gynecological cancer.

Turner, David C; Tillmanns, Todd D; Harstead, K Elaine; Throm, Stacy L; Stewart, Clinton F

Turner, David C; Tillmanns, Todd D; Harstead, K Elaine; Throm, Stacy L; Stewart, Clinton F.

Affiliation

Turner DC; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, U.S.A. clinton.stewart@stjude.org.

Anticancer Res ; 33(9): 3823-9, 2013 Sep.

Article in En | MEDLINE | ID: mdl-24023315

Subject(s)

Angiogenesis Inhibitors/pharmacokinetics; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics; Genital Neoplasms, Female/drug therapy; Administration, Oral; Aged; Angiogenesis Inhibitors/administration & dosage; Angiogenesis Inhibitors/therapeutic use; Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Chromatography, High Pressure Liquid; Female; Humans; Indazoles; Middle Aged; Pyrimidines/administration & dosage; Sulfonamides/administration & dosage; Topotecan/administration & dosage

Key words

Metronomic topotecan; drug drug interaction; gynecological cancer; pazopanib; pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Angiogenesis Inhibitors / Genital Neoplasms, Female Type of study: Prognostic_studies Limits: Aged / Female / Humans / Middle aged Language: En Journal: Anticancer Res Year: 2013 Document type: Article Affiliation country: United States Country of publication: Greece

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