Encapsulation of simvastatin in PLGA microspheres loaded into hydrogel loaded BCP porous spongy scaffold as a controlled drug delivery system for bone tissue regeneration.

Nath, Subrata D; Linh, Nguyen T B; Sadiasa, Alexander; Lee, Byong T

Nath, Subrata D; Linh, Nguyen T B; Sadiasa, Alexander; Lee, Byong T.

Affiliation

Nath SD; Department of Biomedical Engineering and Materials, Soonchunhyang University, Republic of Korea.

J Biomater Appl ; 28(8): 1151-63, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24029488

Subject(s)

Bone Regeneration/drug effects; Drug Delivery Systems; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage; Lactic Acid; Polyglycolic Acid; Simvastatin/administration & dosage; 3T3 Cells; Animals; Bone Regeneration/genetics; Bone Regeneration/physiology; Drug Carriers/chemistry; Drug Compounding; Gene Expression/drug effects; Hydrogels; Hydroxyapatites; Materials Testing; Mice; Microscopy, Electron, Scanning; Microspheres; Osteoblasts/cytology; Osteoblasts/drug effects; Osteoblasts/metabolism; Polylactic Acid-Polyglycolic Acid Copolymer; Tissue Scaffolds/chemistry

Key words

BCP; PLGA; Sponge replica; drug delivery; scaffold; simvastatin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyglycolic Acid / Bone Regeneration / Drug Delivery Systems / Lactic Acid / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin Limits: Animals Language: En Journal: J Biomater Appl Journal subject: ENGENHARIA BIOMEDICA Year: 2014 Document type: Article Country of publication: United kingdom

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