[The results of proton radiosurgery for pituitary endosellar adenomas].
Vopr Onkol
; 59(4): 465-9, 2013.
Article
in Ru
| MEDLINE
| ID: mdl-24032220
ABSTRACT
465 patients with pituitary endosellar adenomas have passed irradiation on the synchrocyclotron PNPI (1000 MeV). Due to the high energy of the proton beam the rotating-convergent shoot-through technique was used. The single dose of 80-100 Gy was given. In patients with prolactin adenomas clinical remission was detected in 80%, and the stabilization of the disease was achieved in 15%. Pregnancies in 21 patients ended in the birth of healthy children, and 4 of them gave the birth twice. Complete clinical remission was observed in 92% of patients with Cushing's disease. Sustained recovery and full normalization of growth hormone level were observed during long-term follow-up in 86% of patients with acromegaly. There was significant reducing of the high hormone level on the fifth year of follow-up in any clinical form of pituitary adenomas while the development of the secondary hypopituitarism was not defected in the most of the patients. Clinical remission in patients with non-secreting adenomas was 95%. Irradiation by the proton beam was not accompanied by serious life-threatening complications. Thus this type of treatment for pituitary endosellar adenomas is highly effective and safe and, sometimes, the only method.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pituitary Hormones
/
Pituitary Neoplasms
/
Adenoma
/
Radiosurgery
/
Proton Therapy
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Ru
Journal:
Vopr Onkol
Year:
2013
Document type:
Article