Linking actin networks and cell membrane via a reaction-diffusion-elastic description of nonlinear filopodia initiation.
Phys Rev E Stat Nonlin Soft Matter Phys
; 88(2): 022718, 2013 Aug.
Article
in En
| MEDLINE
| ID: mdl-24032875
ABSTRACT
Reaction-diffusion models have been used to describe pattern formation on the cellular scale, and traditionally do not include feedback between cellular shape changes and biochemical reactions. We introduce here a distinct reaction-diffusion-elasticity approach:
The reaction-diffusion part describes bistability between two actin orientations, coupled to the elastic energy of the cell membrane deformations. This coupling supports spatially localized patterns, even when such solutions do not exist in the uncoupled self-inhibited reaction-diffusion system. We apply this concept to describe the nonlinear (threshold driven) initiation mechanism of actin-based cellular protrusions and provide support by several experimental observations.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pseudopodia
/
Cell Membrane
/
Actins
/
Nonlinear Dynamics
/
Elasticity
/
Models, Biological
Limits:
Animals
Language:
En
Journal:
Phys Rev E Stat Nonlin Soft Matter Phys
Journal subject:
BIOFISICA
/
FISIOLOGIA
Year:
2013
Document type:
Article
Affiliation country:
Israel