Evaluation of butyrate-induced production of a mannose-6-phosphorylated therapeutic enzyme using parallel bioreactors.

Madhavarao, Chikkathur N; Agarabi, Cyrus D; Wong, Lily; Müller-Loennies, Sven; Braulke, Thomas; Khan, Mansoor; Anderson, Howard; Johnson, Gibbes R

Madhavarao, Chikkathur N; Agarabi, Cyrus D; Wong, Lily; Müller-Loennies, Sven; Braulke, Thomas; Khan, Mansoor; Anderson, Howard; Johnson, Gibbes R.

Affiliation

Madhavarao CN; Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.

Biotechnol Appl Biochem ; 61(2): 184-92, 2014.

Article in En | MEDLINE | ID: mdl-24033810

Subject(s)

Bioreactors; Butyrates/pharmacology; Glucuronidase/biosynthesis; Lysosomal Storage Diseases/enzymology; Animals; Butyrates/chemistry; CHO Cells; Cricetinae; Cricetulus; Glucuronidase/therapeutic use; Humans; Lysosomal Storage Diseases/drug therapy; Lysosomal Storage Diseases/pathology; Mannosephosphates/chemistry; Mannosephosphates/pharmacology; Phosphorylation; Polysaccharides/chemistry

Key words

bioreactors; capillary electrophoresis; enzyme replacement therapies; enzymes; lysosomal storage diseases; mannose-6-phosphate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Butyrates / Lysosomal Storage Diseases / Bioreactors / Glucuronidase Limits: Animals / Humans Language: En Journal: Biotechnol Appl Biochem Journal subject: BIOQUIMICA / BIOTECNOLOGIA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States

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