Quinoline carboxamide-type ABCG2 modulators: indole and quinoline moieties as anilide replacements.
ChemMedChem
; 8(11): 1773-8, 2013 Nov.
Article
in En
| MEDLINE
| ID: mdl-24039190
ABSTRACT
ABC, it's easy as 1 2 3! Bioisosteric replacement of the anilide core by an indole moiety considerably increased stability and gave potent and selective ABCG2 (BCRP) inhibitors. Some compounds are superior to the reference substances fumitremorginâ
C and Ko143 in terms of potency and efficacy and are the most potent ABCG2 modulators reported so far.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phthalic Acids
/
Quinolines
/
ATP-Binding Cassette Transporters
/
Aminoimidazole Carboxamide
/
Indoles
/
Anilides
/
Neoplasm Proteins
Limits:
Humans
Language:
En
Journal:
ChemMedChem
Journal subject:
FARMACOLOGIA
/
QUIMICA
Year:
2013
Document type:
Article
